I had previously installed Python 2.7.2 (32-bit mode) and it's still working fine. It appears that Lion is shipping with 2.7.1 which is probably 64-bit.
Speaking of 64-bit, the National Instruments VISA driver doesn't work with the 64-bit kernel on OS 10 (Lion or Snow Leopard), so if you will be doing VISA stuff in Python, you'll need to boot your computer while holding down the "3" and "2" keys so you get the 32-bit kernel.
The following also work fine with the default 64-bit kernel
Matlab (R2011a)
Qucs (version 0.0.15)
Cisco Anyconnect Client (3.0.2052)
Gerbv (open source circuit board gerber-viewer)
GPSBabelFE
Photomatix Pro was just updated to 4.1 which works on 10.7
Apps with Issues:
PhotoLinker (2.2.9) does not work on 10.7 but there is a Beta that does work (2.5b1)
GPSPhotoLinker (1.6.4) (free version of PhotoLinker) does not work on 10.7
Bart
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